dysplasia binucleate erythroblasts multi Sternberg Interphase translocations neutrophils hypersegmented normoblasts myelocytes oedematous vacuolation haemorrhagic artefact sideroblasts splenomegaly Tdt cytogenetics karyotype binucleate multilineage megaloblastic subcortical macrocytic cytochemistry monocytes leucocytes eosinophils mononuclear sclerosing lymphocytic centromeric stromal monomorphic EDTA trephine cellularity