package LIMS::Model::Local;
use Moose;
extends 'LIMS::Model::Base';
with (
'LIMS::Model::Roles::Query',
'LIMS::Model::Roles::LabTestUpdate', # do_linked_lab_tests()
);
has form_data => ( is => 'rw', isa => 'HashRef', default => sub { {} } );
use namespace::clean -except => 'meta';
__PACKAGE__->meta->make_immutable;
use Data::Dumper;
#-------------------------------------------------------------------------------
sub load_view {
my ($self, $view, $sort) = @_; # warn $sort; # optional sort
my $table = 'views.'.$view;
my $dbix = $self->lims_dbix;
my $data = $dbix->select($table, '*', {}, $sort)->arrays; # $sort ignored if undef
my @cols = map # can't use dbix_get_meta() - need cols in order:
$_->{field}, $dbix->query("show columns from $table")->hashes; # warn Dumper \@cols;
return {
data => $data,
cols => \@cols,
};
}
#-------------------------------------------------------------------------------
sub get_unregistered_requests {
my $self = shift;
my %args = (
query => [ is_screened => 'no' ],
with_objects => 'pre_registration_specimen', # need left join here
);
my $data = LIMS::DB::PreRegistration::Manager->get_pre_registration(%args);
return $data;
}
#-------------------------------------------------------------------------------
sub get_unregistered_request {
my ($self, $id) = @_;
my $data = LIMS::DB::PreRegistration->new(id => $id)->load;
return $data;
}
#-------------------------------------------------------------------------------
sub get_prereg_specimens {
my ($self, $prereg_id) = @_;
my %args = (
query => [ pre_reg_id => $prereg_id ],
);
my $data = LIMS::DB::PreRegistrationSpecimen::Manager
->get_pre_registration_specimens(%args);
return $data;
}
#-------------------------------------------------------------------------------
sub get_unregistered_request_lab_tests {
my $self = shift;
# prereg_specimen_id can be scalar or arrayref:
my $prereg_specimen_id = shift;
my %map;
my %args = (
query => [ reg_specimen_id => $prereg_specimen_id ],
require_objects => 'lab_test',
);
my $data = LIMS::DB::PreRegistrationLabTest::Manager
->get_pre_registration_lab_tests(%args);
for my $prereg_test (@$data) {
my $reg_specimen_id = $prereg_test->reg_specimen_id;
my $test_name = $prereg_test->lab_test->test_name;
$map{$reg_specimen_id}{$test_name} = 1; # just register it
}
return \%map;
}
#-------------------------------------------------------------------------------
sub get_unregistered_request_specimen {
my ($self, $reg_specimen_id) = @_;
my $data = LIMS::DB::PreRegistrationSpecimen
->new(id => $reg_specimen_id)->load(with => 'pre_reg');
return $data;
}
#-------------------------------------------------------------------------------
sub update_pre_registration_data {
my $self = shift;
my $data = shift; # warn Dumper $data;
my $lab_section_id = $data->{lab_section_id};
my $lab_tests_map = $self->_get_lab_tests_map($lab_section_id);
my $db = $self->lims_db; # ie LIMS::DB->new_or_cached;
my $update = sub {
# update pre_registration table:
my $pre_reg = LIMS::DB::PreRegistration->new(
labno => $data->{labno},
)->load;
$pre_reg->surname($data->{surname});
$pre_reg->save( changes_only => 1 );
# create new pre_registration_specimen entry:
my $rs = LIMS::DB::PreRegistrationSpecimen->new(
pre_reg_id => $pre_reg->id,
specimen_code => $data->{specimen},
)->save;
# lab_tests:
while ( my($test_name, $lab_test) = each %$lab_tests_map ) {
next unless $data->{$test_name}; # skip if not in $data
LIMS::DB::PreRegistrationLabTest->new(
reg_specimen_id => $rs->id,
lab_test_id => $lab_test->{id},
)->save;
}
};
my $ok = $db->do_transaction($update);
return $ok ? 0 : 'update_pre_registration_data() error - ' . $db->error;
}
#-------------------------------------------------------------------------------
sub update_pre_registration_specimen_data {
my $self = shift;
my $data = shift; # warn Dumper $data;
my $lab_section_id = $data->{lab_section_id};
my $lab_tests_map = $self->_get_lab_tests_map($lab_section_id);
my $db = $self->lims_db; # ie LIMS::DB->new_or_cached;
my $update = sub {
# get registration_specimen object:
my $rs = LIMS::DB::PreRegistrationSpecimen->new(id => $data->{id})->load;
# get pre_registration object:
my $pre_reg = LIMS::DB::PreRegistration->new(id => $rs->pre_reg_id)->load;
# update pre_registration table (if necessary):
if ($data->{surname} ne $pre_reg->surname) {
$pre_reg->surname($data->{surname});
$pre_reg->save;
}
# update pre_registration_specimen table (if necessary):
if ($data->{specimen} ne $rs->specimen_code) {
$rs->specimen_code($data->{specimen});
$rs->save;
}
{ # clear pre_registration_lab_test table:
my %args = (
where => [ reg_specimen_id => $data->{id} ],
);
LIMS::DB::PreRegistrationLabTest::Manager
->delete_pre_registration_lab_tests(%args);
while ( my($test_name, $lab_test) = each %$lab_tests_map ) {
next unless $data->{$test_name}; # skip if not in $data
LIMS::DB::PreRegistrationLabTest->new(
reg_specimen_id => $data->{id},
lab_test_id => $lab_test->{id},
)->save;
}
}
};
my $ok = $db->do_transaction($update);
return $ok ? 0 : 'update_pre_registration_data() error - ' . $db->error;
}
#-------------------------------------------------------------------------------
sub new_pre_registration_data {
my $self = shift;
my $data = shift; # warn Dumper $data;
my $lab_section_id = $data->{lab_section_id};
my $lab_tests_map = $self->_get_lab_tests_map($lab_section_id);
my $db = $self->lims_db; # ie LIMS::DB->new_or_cached;
my $new_data = sub {
# save pre_registration_specimen data:
my $prereg_specimen = LIMS::DB::PreRegistrationSpecimen->new(
pre_reg_id => $data->{id},
specimen_code => $data->{specimen},
)->save;
# save pre_registration_lab_test data:
while ( my($test_name, $lab_test) = each %$lab_tests_map ) {
next unless $data->{$test_name}; # skip if not in $data
LIMS::DB::PreRegistrationLabTest->new(
reg_specimen_id => $prereg_specimen->id, # new prereg_specimen
lab_test_id => $lab_test->{id},
)->save;
}
};
my $ok = $db->do_transaction($new_data);
return $ok ? 0 : 'new_pre_registration_data() error - ' . $db->error;
}
#-------------------------------------------------------------------------------
sub delete_pre_registration_data {
my ($self, $id) = @_;
=begin # replaced by CASCADE DELETE on pre_reg_specimens & pre_reg_lab_tests FK's:
my $db = $self->lims_db; # ie LIMS::DB->new_or_cached;
my $delete = sub {
my $o = LIMS::DB::PreRegistration->new( id => $id )->load;
{ # get any pre_registration_specimens:
my $specimens = do {
my %args = ( query => [ pre_reg_id => $id ] );
LIMS::DB::PreRegistrationSpecimen::Manager
->get_pre_registration_specimens(%args);
}; # warn Dumper $specimens;
# delete any pre_registration_lab_tests, then delete pre_registration_specimens:
for my $specimen (@$specimens) {
my $id = $specimen->id;
my %args = ( where => [ reg_specimen_id => $id ] );
LIMS::DB::PreRegistrationLabTest::Manager
->delete_pre_registration_lab_tests(%args);
LIMS::DB::PreRegistrationSpecimen->new(id => $id)->delete;
}
}
# now delete pre_registration entry:
$o->delete; # die 'roll back now';
};
my $ok = $db->do_transaction($delete);
return $ok ? 0 : 'delete_pre_registration_data() error - ' . $db->error;
=cut
eval { LIMS::DB::PreRegistration->new( id => $id )->delete };
return @$ if @$;
}
#-------------------------------------------------------------------------------
sub has_previous_data {
my ($self, $args) = @_;
my $test_name = $args->{test_name};
my $request = $args->{request};
my $patient_id = $request->patient_case->patient_id;
my @args = (
require_objects => [
qw( patient_case.patient request_lab_tests_status.lab_test )
],
query => [
'requests.id' => { lt => $request->id },
patient_id => $patient_id,
test_name => $test_name,
],
);
# need at least 1 previous dataset on same patient:
my $i = LIMS::DB::Request::Manager->get_requests_count(@args);
return $i;
}
#-------------------------------------------------------------------------------
sub get_chimerism_data {
my ($self, $request_id) = @_; # warn Dumper $request_id; # arrayref
my %h;
{ # request & patient data:
my @args = (
require_objects => [ 'patient_case.patient' ],
with_objects => [ 'patient_case.patient.patient_note' ],
query => [ id => $request_id ],
);
my $o = LIMS::DB::Request::Manager->get_requests(@args);
for my $req(@$o) { # warn Dumper $req->as_tree;
my $id = $req->id;
$h{$id} = $req->as_tree(deflate => 0); # hash ref so we can add more data
}
}
{ # sample data:
my @args = (
require_objects => [ 'specimen' ],
query => [ request_id => $request_id ],
);
my $o = LIMS::DB::RequestSpecimen::Manager->get_objects(@args);
for my $ref(@$o) {
my $id = $ref->request_id; # should only be 1 sample (CHIx) but jic
push @{ $h{$id}{specimen} }, $ref->specimen->sample_code;
}
}
{ # lab-tests:
my @args = (
require_objects => [ 'lab_test' ],
query => [
request_id => $request_id,
'lab_test.test_name' => { rlike => 'chimerism' },
'lab_test.is_active' => 'yes',
],
);
my $o = LIMS::DB::RequestLabTestStatus::Manager->get_objects(@args);
for my $ref(@$o) {
my $id = $ref->request_id;
push @{ $h{$id}{lab_test} }, $ref->lab_test->field_label;
}
}
my @rels = ( 'patient_case.patient', 'results_summary.lab_section',
'request_specimen.specimen' );
# common args for baseline & previous results (will be cloned in loop):
my $ARGS = {
baseline => {
require_objects => \@rels,
query => [
'results_summary.lab_section.section_name' => 'Molecular',
'request_specimen.specimen.sample_code' => 'CHIB',
],
multi_many_ok => 1, # have >1 "one to many" relationships (get arrayrefs)
},
previous => {
require_objects => \@rels,
query => [
'results_summary.lab_section.section_name' => 'Molecular',
'request_specimen.specimen.sample_code' => [ qw(CHIA CHIM) ],
],
multi_many_ok => 1, # have >1 "one to many" relationships (get arrayrefs)
sort_by => [ 'created_at DESC' ],
limit => 1,
},
};
my $clone = sub { LIMS::Local::Utils::clone(@_) };
{ # baseline & most recent data (if CHI[AM] sample):
REQ: while ( my($req_id, $d) = each %h ) { # warn Dumper $d;
my $specimen = $d->{specimen}; # arrayref (should be of 1)
next REQ unless grep $_ =~ /CHI[AM]/, @$specimen;
my $nhs_number = $d->{patient_case}->{patient}->{nhs_number}
|| next REQ; # or will query db using nhs_number => NULL
{ # baseline (CHIB) data:
my $args = &$clone($ARGS->{baseline}); # take copy for modification
push @{ $args->{query} },
'patient_case.patient.nhs_number' => $nhs_number; # warn Dumper $args;
my $o = LIMS::DB::Request::Manager->get_objects(%$args);
if ( @$o ) { # warn Dumper $o; # should be array(ref) of 1 arrayref:
my $result = $o->[0]->results_summary->[0]->results_summary;
my ($baseline) = $result =~ /Baseline chimerism data:\s?(.*)/;
$h{$req_id}{baseline} = $baseline;
}
}
{ # previous (CHIA/M) molecular result:
my $args = &$clone($ARGS->{previous}); # take copy for modification
push @{ $args->{query} },
'patient_case.patient.nhs_number' => $nhs_number; # warn Dumper $args;
my $o = LIMS::DB::Request::Manager->get_objects(%$args);
if ( @$o ) { # warn Dumper $o; # should be array(ref) of 1 arrayref:
my $result = $o->[0]->results_summary->[0]->results_summary;
$h{$req_id}{previous_result} = $result;
}
}
}
}
return \%h;
}
#-------------------------------------------------------------------------------
sub get_xna_extraction_status {
my ($self, $args) = @_; # warn Dumper $args; # hashref
my $request_id = $args->{request_id};
my $lab_test_id = $args->{lab_test_id};
my @linked_lab_test_ids = do {
my @args = (
distinct => 1,
select => 'linked_test_id',
query => [ parent_test_id => $lab_test_id ],
);
my $o = LIMS::DB::LinkedLabTest::Manager->get_objects(@args);
map $_->linked_test_id, @$o;
}; # warn Dumper \@linked_lab_test_ids;
my $data = LIMS::DB::Request::Manager->get_objects(
require_objects => [
'request_lab_tests_status.status',
'request_lab_tests_status.lab_test'
],
query => [
id => $request_id,
'request_lab_tests_status.lab_test.id' => \@linked_lab_test_ids,
],
); # warn Dumper $_->as_tree for @$data;
return $data;
}
#-------------------------------------------------------------------------------
sub pcr_status_overview {
my ($self, $lab_test_id) = @_; # arrayref
my $data = LIMS::DB::RequestLabTestStatus::Manager->get_objects(
query => [
'request.status_option.description' => { ne => 'complete '},
'lab_test_id' => $lab_test_id,
],
require_objects => [ 'status', 'lab_test', 'request.status_option' ],
sort_by => [
qw( request.request_number request.year lab_test.test_name )
],
); # warn Dumper $_->as_tree for @$data;
return $data;
}
#-------------------------------------------------------------------------------
sub get_selected_request_lab_test_results {
my ($self, $params) = @_;
my %args = (
query => [ %$params ],
require_objects => 'lab_test',
);
my $lab_test_results = LIMS::DB::RequestLabTestResult::Manager
->get_request_lab_test_results(%args);
return $lab_test_results;
}
#-------------------------------------------------------------------------------
sub get_outstanding_gross_description {
my $self = shift;
my @inner_joins = qw( patients sample_code status_options );
my $require_objects_relationships = $self->get_relationships(\@inner_joins);
my @outer_joins = qw(request_specimen_detail);
my $with_objects_relationships = $self->get_relationships(\@outer_joins);
my %args = (
query => [
'status_option.description' => [ qw(new screened) ] , # ie not reported
'specimens.description' => { rlike => '(fixed|trephine)$' },
gross_description => undef,
],
# retrieve distinct records (but can only retrieve 1 sample per request):
distinct => [ qw(request_specimen patient_case patient specimen) ],
require_objects => $require_objects_relationships,
with_objects => $with_objects_relationships,
multi_many_ok => 1, # have >1 one-to-many rels
);
my $o = LIMS::DB::Request::Manager->get_requests(%args);
return $o;
}
#-------------------------------------------------------------------------------
sub update_gross_description {
my ($self, $args) = @_; # warn Dumper $args;
my $db = $self->lims_db;
my $request_id = $args->{request_id};
my $gross_desc = $args->{gross_description};
my $update = sub {
my $o = LIMS::DB::RequestSpecimenDetail->new(request_id => $request_id);
my $action = $o->load_speculative ? 'updated' : 'reported'; # warn Dumper $o->as_tree;
$o->gross_description($gross_desc);
$o->insert_or_update(changes_only => 1); # don't update specimen_date if exists
LIMS::DB::RequestHistory->new(
request_id => $args->{request_id},
user_id => $self->user_profile->{id},
action => join ' ', $action, 'specimen gross description',
)->save;
};
my $ok = $db->do_transaction($update);
return $ok ? 0 : 'update_gross_description() error - ' . $db->error;
}
#-------------------------------------------------------------------------------
sub update_histology_data {
my $self = shift;
my $data = shift; # warn Dumper $data;
my $user_profile = $self->user_profile;
my $lab_test = LIMS::DB::LabTest->new(id => $data->{lab_test_id})->load;
my $field_label = $lab_test->field_label;
my $lab_section_id = $data->{lab_section_id};
my $linked_tests = $data->{linked_tests} || {}; # optional href (yaml data)
my $user_id = $data->{user_id};
my $alias;
unless ( $user_id == $user_profile->{id} ) {
$alias = LIMS::DB::User->new(id => $user_id)->load;
}
# get status options for lab_section:
my $status_options = $self->_get_lab_section_status_options($lab_section_id);
my $lab_tests = $self->_get_lab_tests_map($lab_section_id); # warn Dumper $lab_tests;
my $db = $self->lims_db; # ie LIMS::DB->new_or_cached;
my $update = sub {
# update request_lab_test_history table
for my $option_name (@$status_options) { # warn Dumper $option_name;
next unless $data->{$option_name};
my $action = "set $field_label status to $option_name";
if ( $alias ) { # ie data entered on behalf of different user
$action .= sprintf ' for %s', uc $alias->username;
}
my %data = (
request_id => $data->{request_id},
user_id => $user_profile->{id},
action => $action,
);
LIMS::DB::RequestLabTestHistory->new(%data)->save;
# update request_lab_test_status if 'complete':
if ($option_name eq 'complete') {
# get status option for 'complete':
my $status_option = LIMS::DB::LabTestStatusOption
->new(description => 'complete')->load;
my %h = (
request_id => $data->{request_id},
lab_test_id => $data->{lab_test_id},
);
my $o = LIMS::DB::RequestLabTestStatus->new(%h)->load;
# update status option & user_id:
$o->status_option_id($status_option->id);
$o->user_id($user_profile->{id});
$o->save(changes_only => 1);
}
# linked additional tests if configured:
if ( my $tests = $linked_tests->{$option_name} ) { # warn Dumper $tests;
$self->do_linked_lab_tests($tests, $data->{request_id});
}
}
# update test results:
TEST:
while ( my($test_name, $lab_test) = each %$lab_tests ) {
next TEST unless $lab_test->{has_results} eq 'yes'; # skip unless resultable
next TEST unless $data->{$test_name}; # skip unless data input - so can't remove
my %data = (
request_id => $data->{request_id},
lab_test_id => $lab_test->{id},
); # warn Dumper \%data;
my $o = LIMS::DB::RequestLabTestResult->new(%data);
my $action;
if ( $o->load(speculative => 1) ) {
my $old_result = $o->result;
next TEST if $old_result eq $data->{$test_name};
$o->result($data->{$test_name});
$o->save(changes_only => 1);
$action = sprintf 'updated %s result [%s -> %s]',
$lab_test->{field_label}, $old_result, $data->{$test_name};
}
else {
$o->result($data->{$test_name});
$o->save;
$action = "entered new $lab_test->{field_label} result";
}
{ # log changes:
my %data = (
request_id => $data->{request_id},
user_id => $user_profile->{id},
action => $action,
);
LIMS::DB::RequestLabTestHistory->new(%data)->save;
}
}
};
my $ok = $db->do_transaction($update);
return $ok ? 0 : 'update_histology_data() error - ' . $db->error;
}
#-------------------------------------------------------------------------------
sub update_histology_blocks {
my ($self, $data) = @_;
my $db = $self->lims_db; # ie LIMS::DB->new_or_cached;
my $request_ids = $data->{request_ids};
my $ref = $data->{reference}; # changed to a recorded delivery ref
my $user_profile = $self->user_profile;
my $update = sub {
# update request_external_ref table
for my $id (@$request_ids) {
my $o = LIMS::DB::RequestExternalRef->new(request_id => $id)->load;
$o->status($ref);
$o->save(changes_only => 1);
{ # log changes:
my $action = sprintf 'returned blocks [ref: %s]', $ref;
my %data = (
request_id => $id,
user_id => $user_profile->{id},
action => $action,
);
LIMS::DB::RequestLabTestHistory->new(%data)->save;
}
}
};
my $ok = $db->do_transaction($update);
return $ok ? 0 : 'update_histology_blocks() error - ' . $db->error;
}
#-------------------------------------------------------------------------------
sub _get_lab_section_status_options {
my ($self, $lab_section_id) = @_;
my %q = (
query => [ lab_section_id => $lab_section_id ],
require_objects => 'status_option',
sort_by => 'position',
);
my $o = LIMS::DB::LabSectionStatusOption::Manager
->get_lab_section_status_option(%q);
my @options = map {
$_->status_option->description;
} @$o;
push @options, 'complete'; # need this also
return \@options;
}
#-------------------------------------------------------------------------------
sub _get_lab_tests_map {
my ($self, $lab_section_id) = @_;
# get available lab_tests for pre_screen:
my %args = (
query => [
lab_section_id => $lab_section_id,
is_active => 'yes',
],
);
my $lab_tests = LIMS::DB::LabTest::Manager->get_lab_tests(%args);
my %lab_test_map = map {
$_->test_name => $_->as_tree,
} @$lab_tests; # warn Dumper \%lab_test_map;
return \%lab_test_map;
}
1;